Tolerance to anticholinesterase compounds in mammals
| Autor: | Bradley W. Schwab, Sheldon D. Murphy, Lucio G. Costa |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Insecticides
Organophosphate Drug Tolerance Receptors Nicotinic Biology Pharmacology Toxicology Receptors Muscarinic Acetylcholinesterase chemistry.chemical_compound Organophosphorus Compounds Parasympathomimetics Downregulation and upregulation chemistry Parasympathetic Nervous System In vivo Toxicity Muscarinic acetylcholine receptor Animals Cholinergic Carbamates Cholinesterase Inhibitors Receptor |
| Zdroj: | Toxicology. 25:79-97 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(82)90021-x |
| Popis: | Administration of multiple, sublethal doses of organophosphorus insecticides induces the development of tolerance to their toxicity. Among the differebt hypotheses investigated to explain the mechanism of this phenomenon, the one which has received the greatest experimental support is a downregulation of the muscarinic cholinergic receptors. Subsensitivity to cholinergic agonist has been demonstrated in vivo and in vitro in isolated organ preparations. Receptor bindng experiments using muscarinicantagonists and agonists revealed a decrease of cholinergic receptors in central and peripheral tissues. Tolerance to another class of acetylcholinesterase inhibitors, carbamates has also been demonstrated. Difference from and similarities to organophosphate tolerance are discussed. |
| Databáze: | OpenAIRE |
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