The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland
| Autor: | R. Margareta Müller, Godfried M. Roomans |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Reserpine Cystic Fibrosis Clinical Biochemistry Terbutaline Submandibular Gland chemistry.chemical_element Calcium Cystic fibrosis Pathology and Forensic Medicine Acinus Internal medicine medicine Animals Drug Interactions Magnesium Molecular Biology Isoproterenol Rats Inbred Strains medicine.disease Mucus Submandibular gland Rats Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Prenalterol Potassium Female medicine.drug Electron Probe Microanalysis |
| Zdroj: | Experimental and molecular pathology. 40(3) |
| ISSN: | 0014-4800 |
| Popis: | The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis. Ultrastructural studies showed enlarged cells with abnormally large mucus granules that were more often fused than in control animals. X-ray microanalysis of mucous acinar cells showed a significant increase in calcium levels, but unaffected magnesium levels. Combined treatment with isoproterenol and reserpine caused a very large increase in cellular calcium levels that appeared to be an addition of the single effects and increased magnesium levels (as in glands of rats treated with reserpine only). Chronic treatment with isoproterenol, reserpine, or both substances tended to decrease cellular potassium levels. Chronic exposure to the specific beta 1-agonist prenalterol or the specific beta 2-agonist terbutaline did not affect cellular calcium or potassium levels. It is concluded that chronic isoproterenol treatment affects the elemental composition of mucous acinar cells of rat submandibular gland differently from chronic reserpine treatment. The increase in cellular calcium concentration after chronic isoproterenol treatment does not appear to be due to an effect via beta-adrenergic receptors. |
| Databáze: | OpenAIRE |
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