A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
| Autor: | Shuichi Yoshihara, Masahiko Endo, Keiichi Takagaki, Hideaki Nakazawa, Mutsuo Sasaki, Daisuke Kudo, Ikuko Kakizaki, Atsushi Kon |
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| Rok vydání: | 2005 |
| Předmět: |
Melanoma cell
Cell Melanoma Experimental Biophysics Administration Oral Antineoplastic Agents Biochemistry Metastasis Glycosaminoglycan Mice chemistry.chemical_compound Cell Movement Structural Biology In vivo Cell Adhesion Genetics medicine Animals Glucuronosyltransferase Neoplasm Metastasis Cell adhesion Molecular Biology Hyaluronan Hymecromone 4-Methylumbelliferone biology Melanoma Liver Neoplasms Cell Biology medicine.disease Mice Inbred C57BL Hyaluronan synthase medicine.anatomical_structure Liver chemistry biology.protein Cancer research Female Hyaluronan Synthases |
| Zdroj: | FEBS Letters. 579:2722-2726 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2005.03.079 |
| Popis: | 4-Methylumbelliferone (MU) inhibits the cell surface hyaluronan (HA) formation, and that such inhibition results in suppression of adhesion and locomotion of cultured melanoma cells. Here, we examine the effect of MU on melanoma cell metastasis in vivo. MU-treated melanoma cells showed both decreased cell surface HA formation and suppression of liver metastasis after injection into the mice. Oral administration of MU to mice decreased tissue HA content. These HA knock-down mice displayed suppressed liver metastasis. Thus, both cell surface HA of melanoma cells and recipient liver HA can promote liver metastasis, indicating that MU has potential as an anti-metastatic agent. |
| Databáze: | OpenAIRE |
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