Examination of Diagnostic Accuracy of UroVysion Fluorescence In Situ Hybridization for Bladder Cancer in a Single Community of Japanese Hospital Patients
| Autor: | Hidetoshi Akita, Yoshinobu Moritoki, Takashi Nagai, Daichi Kobayashi, Ryosuke Chaya, Takehiko Okamura, Takahiro Yanase, Takahiro Yasui |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Urinary bladder carcinoma medicine.medical_specialty Cytodiagnosis Urology UroVysion Diagnostic accuracy Urine 03 medical and health sciences 0302 clinical medicine FISH Predictive Value of Tests Cytology medicine Carcinoma Humans In Situ Hybridization Fluorescence Aged Urine cytology Aged 80 and over Bladder cancer medicine.diagnostic_test business.industry Cystoscopy General Medicine Middle Aged medicine.disease 030104 developmental biology ROC Curve Urinary Bladder Neoplasms 030220 oncology & carcinogenesis cytology Female Reagent Kits Diagnostic business Research Article Follow-Up Studies Fluorescence in situ hybridization |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Objective: UroVysion (Abbott Molecular, Inc., Illinois, USA) is based on multicolor fluorescence in situ hybridization (FISH). It has been used successfully in the USA following its Food and Drug Administration approval in 2001. However, the technology was not approved for use in Japan until 2017. Cystoscopy and urine cytology are the most frequently used examinations to detect bladder cancer in Japan, and there are only a few reports regarding the performance of UroVysion. Therefore, the aim of this study is to examine the diagnostic accuracy of UroVysion FISH in Japanese patients whose tumors are detected by cystoscopy before transurethral resection of bladder tumor (TURBT). Methods: From April 2018 to July 2018, a total of 40 patients who were diagnosed as having bladder tumors by cystoscopy, and therefore underwent TURBT were registered in this study. One day before TURBT, urine cytology and UroVysion FISH were used in order to compare the accuracy with which they could detect bladder carcinoma, as confirmed by pathological results of TURBT. Results: The pathological results of TURBT showed urothelial carcinoma in 33 cases. Urine cytology showed positive results for 0 cases (0%), suspicious results for 10 cases (30.3%), and negative results for 23 cases (69.7%). On the other hand, UroVysion FISH indicated 9 positive cases (27.3%) and 24 negative cases (72.7%). There were 19 cases of urothelial carcinoma (57.6%) that were not detected by either method. Conclusion: We conclude that UroVysion FISH alone is insufficient to detect bladder cancer and that cystoscopy is essential for the optimum detection or follow up of bladder cancer cases in our hospital. |
| Databáze: | OpenAIRE |
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