Inherited ichthyoses: molecular causes of the disease in Czech patients

Autor: Kamila Réblová, Jitka Němečková, Lenka Kopečková, Hana Bučková, Alena Puchmajerová, Markéta Hermanová, Lenka Fajkusová, Blanka Pinková, Romana Borská, Marcela Malíková
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-5 (2019)
Orphanet Journal of Rare Diseases
ISSN: 1750-1172
Popis: Inherited ichthyoses belong to a large and heterogeneous group of mendelian disorders of cornification, and can be distinguished by the quality and distribution of scaling and hyperkeratosis, by other dermatologic and extracutaneous involvement, and by inheritance. We present the genetic analysis results of probands with X-linked ichthyosis, autosomal recessive congenital ichthyosis, keratinopathic ichthyosis, and a patient with Netherton syndrome. Genetic diagnostics was complemented by in silico missense variant analysis based on 3D protein structures and commonly used prediction programs to compare the yields of these two approaches to each other. This analysis revealed various structural defects in proteins coded by mutated genes while no defects were associated with known polymorphisms. Two patients with pathogenic variants in the ABCA12 gene have a premature termination codon mutation on one allele and a silent variant on the second. The silent variants c.69G > A and c.4977G > A are localised in the last nucleotide of exon 1 and exon 32, respectively, and probably affect mRNA splicing. The phenotype of both patients is very severe, including a picture harlequin foetus after birth; later (at 3 and 6 years of age, respectively) ectropin, eclabion, generalised large polygonal scaling and erythema. Electronic supplementary material The online version of this article (10.1186/s13023-019-1076-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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