DeltaNp63alpha promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82

Autor: Matteo Pecoraro, L Batlle-Morera, Tian V. Tian, Alba Mas, L Noya, J Martín-Caballero, V Di Giacomo, J Ruberte, W M Keyes
Přispěvatelé: Barcelona Institute of Science and Technology (BIST), Universitat Pompeu Fabra [Barcelona] (UPF), Universitat Autònoma de Barcelona (UAB), Barcelona Biomedical Research Park (PRBB), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte, Keyes, Bill
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Cancer Research
[SDV]Life Sciences [q-bio]
Bone Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
Kangai-1 Protein
Mice
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Bone Neoplasms
secondary
[SDV.CAN] Life Sciences [q-bio]/Cancer
Cancer stem cell
Cell Line
Tumor
Cell Adhesion
Prostatic Neoplasms
pathology
Transcription Factors
physiology
Genetics
medicine
Animals
Humans
Progenitor cell
Cell adhesion
Molecular Biology
Oncogene
Tumor Suppressor Proteins
Prostatic Neoplasms
Cancer
medicine.disease
Tumor Suppressor Proteins
physiology
Cell biology
Mice
Inbred C57BL
[SDV] Life Sciences [q-bio]
030104 developmental biology
Gene Expression Regulation
030220 oncology & carcinogenesis
Adenocarcinoma
Original Article
Stem cell
Kangai-1 Protein
physiology
Transcription Factors
Zdroj: Oncogene
Oncogene, 2017, 36 (31), pp.4381-4392. ⟨10.1038/onc.2017.42⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 2009-2482
0950-9232
1476-5594
DOI: 10.1038/onc.2017.42⟩
Popis: Altres ajuts: Marie Curie International Reintegration Grant PIRG5-GA-2009-248262 ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer stem cell properties in squamous cell carcinoma. However, with regards to the prostate, while ΔNp63α is expressed in the basal stem cells of the mature gland, during adenocarcinoma development, its expression is lost and its absence is used to clinically diagnose the malignant state. Surprisingly, here we identify a sub-population of bone metastatic prostate cancer cells in the PC3 cell line that express ΔNp63α. Interestingly, we discovered that ΔNp63α favors adhesion and stem-like growth of these cells in the bone microenvironment. In addition, we show that these properties require expression of the target gene CD82. Together, this work uncovers a population of bone metastatic prostate cancer cells that express ΔNp63α, and provides important information about the mechanisms of bone metastatic colonization. Finally, we identify metastasis-promoting properties for the tetraspanin family member CD82.
Databáze: OpenAIRE
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