Cognitive consequences of regression of cerebral small vessel disease
| Autor: | Frank-Erik de Leeuw, Esther M.C. van Leijsen, Ingeborg W.M. van Uden, Sjacky Cooijmans, Anil M. Tuladhar, Mohsen Ghafoorian, Mayra I. Bergkamp, Helena M. van der Holst, David G. Norris, Roy P. C. Kessels, Bram Platel |
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| Přispěvatelé: | Neurology |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] Biophysics Medizin Disease 030204 cardiovascular system & hematology 150 000 MR Techniques in Brain Function 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Neuroimaging Original Research Articles Internal medicine medicine Cognitive decline Neuro- en revalidatiepsychologie medicine.diagnostic_test business.industry Data Science Neuropsychology and rehabilitation psychology Magnetic resonance imaging Cognition Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Regression Cardiology Neurology (clinical) Small vessel Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | European Stroke Journal, 4, 85-89 European Stroke Journal, 4, 1, pp. 85-89 van Leijsen, E M C, Bergkamp, M I, van Uden, I W M, Cooijmans, S, Ghafoorian, M, van der Holst, H M, Norris, D G, Kessels, R P C, Platel, B, Tuladhar, A M & de Leeuw, F-E 2019, ' Cognitive consequences of regression of cerebral small vessel disease ', European Stroke Journal, vol. 4, no. 1, pp. 85-89 . https://doi.org/10.1177/2396987318820790 European Stroke Journal, 4(1), 85-89. SAGE Publications Inc. |
| ISSN: | 2396-9881 2396-9873 |
| DOI: | 10.1177/2396987318820790 |
| Popis: | Introduction Recent studies have shown that neuroimaging markers of cerebral small vessel disease can also regress over time. We investigated the cognitive consequences of regression of small vessel disease markers. Patients and methods Two hundred and seventy-six participants of the RUNDMC study underwent neuroimaging and cognitive assessments at three time-points over 8.7 years. We semi-automatically assessed white matter hyperintensities volumes and manually rated lacunes and microbleeds. We analysed differences in cognitive decline and accompanying brain atrophy between participants with regression, progression and stable small vessel disease by analysis of variance. Results Fifty-six participants (20.3%) showed regression of small vessel disease markers: 31 (11.2%) white matter hyperintensities regression, 10 (3.6%) vanishing lacunes and 27 (9.8%) vanishing microbleeds. Participants with regression showed a decline in overall cognition, memory, psychomotor speed and executive function similar to stable small vessel disease. Participants with small vessel disease progression showed more cognitive decline compared with stable small vessel disease (p Discussion Regression of small vessel disease markers was associated with similar cognitive decline compared to stable small vessel disease and did not accompany brain atrophy, suggesting that small vessel disease regression follows a relatively benign clinical course. Future studies are required to validate these findings and to assess the role of vascular risk factor control on small vessel disease regression and possible recovery of clinical symptoms. Conclusion Our findings of comparable cognitive decline between participants with regression and stable small vessel disease might suggest that small vessel disease regression has a relative benign cognitive outcome. |
| Databáze: | OpenAIRE |
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