Serum Concentrations of Selected Organochlorines in Pregnant Women and Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural Settings in Cambodia
| Autor: | Sam Ol Ha, Shanshan Xu, Jon Øyvind Odland, Margit Steinholt, Maria Lisa Odland, Duong Trong Phi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cross-sectional study Heptachlor Epoxide polychlorinated biphenyls low-resource settings Health Toxicology and Mutagenesis Birth weight pregnancy outcomes Population lcsh:Medicine 010501 environmental sciences 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine organochlorine pesticides Pregnancy Hydrocarbons Chlorinated Humans Medicine 030212 general & internal medicine Pesticides Pregnancy outcomes education 0105 earth and related environmental sciences education.field_of_study business.industry lcsh:R Infant Newborn Pregnancy Outcome Public Health Environmental and Occupational Health stunting Gestational age Hexachlorobenzene neonatal health Cross-Sectional Studies chemistry Environmental Pollutants Female Pregnant Women Cambodia business Parity (mathematics) Demography |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 20 International Journal of Environmental Research and Public Health (IJERPH) International Journal of Environmental Research and Public Health, Vol 17, Iss 7652, p 7652 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17207652 |
| Popis: | We conducted a cross-sectional study among 194 pregnant women from two low-income settings in Cambodia. The inclusion period lasted from October 2015 through December 2017. Maternal serum samples were analyzed for persistent organic pollutants (POPs). The aim was to study potential effects on birth outcomes. We found low levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCP), except for heptachlors, &beta hexachlorocyclohexane (HCH), heptachlor epoxide, and p,p&rsquo DDE. There were few differences between the two study locations. However, the women from the poorest areas had significantly higher concentrations of p,p&rsquo DDE (p < 0.001) and hexachlorobenzene (HCB) (p = 0.002). The maternal factors associated with exposure were parity, age, residential area, and educational level. Despite low maternal levels of polychlorinated biphenyls, we found significant negative associations between the PCB congeners 99 (95% CI: &minus 2.51 to &minus 0.07), 138 (95% CI: &minus 1.28 to &minus 0.32), and 153 (95% CI: &minus 1.06 to &minus 0.05) and gestational age. Further, there were significant negative associations between gestational age, birth length, and maternal levels of o,p&rsquo DDE. Moreover, o,p&rsquo DDD had positive associations with birth weight, and both p,p&rsquo DDD and o,p&rsquo DDE were positively associated with the baby&rsquo s ponderal index. The poorest population had higher exposure and less favorable outcomes. |
| Databáze: | OpenAIRE |
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