Ocular involvement in systemic lupus erythematosus patients: a paradigm shift based on the experience of a tertiary referral center

Autor:	Ana Luísa Papoila, Rui Proença, Marta Alves, João Paulo Cunha, Arnaldo Dias-Santos, M Francisca Moraes-Fontes, Sofia Pinheiro, J. Tavares Ferreira
Rok vydání:	2020
Předmět:	Adult Male Pediatrics medicine.medical_specialty genetic structures Drug-Related Side Effects and Adverse Reactions Eye Diseases Visual Acuity Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Rheumatology Retinal Diseases Prevalence Medicine Humans Lupus Erythematosus Systemic Prospective Studies 030203 arthritis & rheumatology business.industry Middle Aged eye diseases Antirheumatic Agents Cohort 030221 ophthalmology & optometry Referral center Female sense organs business Tomography Optical Coherence Hydroxychloroquine
Zdroj:	Lupus. 29(3)
ISSN:	1477-0962
Popis:	Objective To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature. Methods Patients underwent a complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold visual fields, fundus autofluorescence and spectral-domain optical coherence tomography to screen for hydroxychloroquine (HCQ) macular toxicity. Results A total of 161 patients (16 men and 145 women) were enrolled in this study. The mean age was 47.6 years and the mean disease duration was 11.5 years. Fifty patients (31.1%) had at least one ocular manifestation of SLE. The most frequent manifestation was dry eye syndrome (12.4%), immediately followed by cataracts (11.2%) and HCQ macular toxicity (11.2%). Among patients with HCQ maculopathy, two presented with an atypical spectral-domain optical coherence tomography pattern. Five patients (3.1%) presented with glaucoma, two patients (1.2%) presented with SLE retinopathy while only one presented with lupus choroidopathy (0.6%). Conclusions Compared with previous studies, we conclude there has been a significant reduction in disease-related ocular complications, particularly those associated with poor systemic disease control. On the other hand, drug and age-related complications are assuming a prominent role in the ophthalmic care of these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fab0595f9deabd32ab6ac71272f23e0 https://pubmed.ncbi.nlm.nih.gov/31992127 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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