Diagnosis of atopic dermatitis in children: comparison of the Hanifin-Rajka and the United Kingdom Working Party criteria
| Autor: | Ayşegül Akan, Can Naci Kocabaş, Emine Vezir, Emine Dibek-Mısırlıoğlu, Ersoy Civelek |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Immunology Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Immunology and Allergy Chronic skin disease Clinical efficacy Child business.industry Significant difference Gold standard Infant General Medicine Atopic dermatitis medicine.disease Clinical trial 030228 respiratory system Child Preschool Clinical diagnosis Female business 030215 immunology |
| Zdroj: | Allergologia et Immunopathologia. 48:175-181 |
| ISSN: | 0301-0546 |
| Popis: | Background Atopic dermatitis (AD) is the most common chronic skin disease in childhood. There is no definitive test for diagnosing AD. The Hanifin-Rajka criteria (HRC) and The United Kingdom Working Party criteria (UKC) are the most used in the literature. It is aimed to evaluate the clinical efficacy of HRC and UKC in pediatric age. Methods Children diagnosed AD in the pediatric allergy clinic were enrolled. Patients with skin problems other than AD were involved as controls. All participants were evaluated for HRC and UKC at the time of diagnosis. Clinical diagnosis by the pediatric allergist was determined as the gold standard. Results 200 children with AD and 90 controls were enrolled in the study. Median (interquartile range, IQR) age of AD patients was 13.5 (7–36) months. There was no significant difference in age and sex between groups (p = 0.11 and p = 0.34, respectively). The HRC were superior to the UKC for sensitivity, negative predictive value, kappa and accuracy rate (94% vs. 72%, 84% vs. 60%, 0.68 vs. 0.56 and 87 vs. 78, respectively). On the other hand, specificity and positive predictive value of UKC were better than those of HRC (92% vs. 71% and 95% vs. 88%, respectively). Conclusion HRC seem to be better in diagnosing AD than UKC for young children. Further studies are needed to evaluate comparableness of HRC and UKC for AD in childhood in order to generate an international consensus for clinical trials. |
| Databáze: | OpenAIRE |
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