Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood
| Autor: | Melissa S Liebling, Peter Andrew Marcovici, Walter E. Berdon |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Osteochondroma
medicine.medical_specialty Bone Tuberculosis Bone marrow transplant Transplantation Conditioning Group ii External beam radiation Bone Neoplasms Radiation Dosage Therapeutic radiation Bone and Bones Tuberculosis Osteoarticular Neoplasms Humans Medicine Radiology Nuclear Medicine and imaging Child Growth Disorders Bone Marrow Transplantation Bone Development Radiotherapy Growth retardation business.industry Thorium Infant Total body irradiation Surgery Pediatrics Perinatology and Child Health Radiology Radiopharmaceuticals business Whole-Body Irradiation Radium |
| Zdroj: | Pediatric Radiology. 37:301-304 |
| ISSN: | 1432-1998 0301-0449 |
| DOI: | 10.1007/s00247-006-0382-0 |
| Popis: | For over five decades, osteochondromas (exostoses) and associated growth retardation have been known to be caused by radiation damage to the growing skeleton. Patients can be divided into three exposure groups. Group I received external beam radiation therapy primarily for the treatment of childhood cancers (typical dose 3,500 cGy), and 6-20% developed osteochondromas and growth retardation within the radiation portal. Group II consists of recently described patients who received total body irradiation in preparation for bone marrow transplant (typical dose: 800-1,200 cGy), and about 20% developed osteochondromas and growth retardation. Group III consists of 206 German children who in the 1940s and early 1950s received intravenous radioactive Peteosthor (Ra-224) to treat bone tuberculosis (estimated typical dose: 1,000-2,000 cGy), and 14% developed osteochondromas and growth retardation, among other benign and malignant sequelae. Combining these three exposure groups, osteochondromas and growth retardation develop in at least 6-20% of children who receive therapeutic radiation to their growing skeletons. |
| Databáze: | OpenAIRE |
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