Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure
| Autor: | Orietta Picconi, Paolo Pasquini, Peter Boyle, Maria Sofia Cattaruzza, Sara Gandini, Francesco Sera, C.F. Melchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Neoplasms Radiation-Induced Skin Neoplasms Adolescent Cohort Studies sunburn Risk Factors Epidemiology medicine melanoma Humans Sunburn Risk factor skin and connective tissue diseases Child Aged Sunlight business.industry Case-control study review literature Middle Aged medicine.disease Dermatology meta-analysis Oncology epidemiology sunlight Relative risk Meta-analysis Case-Control Studies Cutaneous melanoma Chronic Disease business |
| Popis: | A systematic revision of the literature was conducted in order to undertake a comprehensive meta-analysis of all published observational studies on melanoma. An extensive analysis of the inconsistencies and variability in the estimates was performed to provide some clues about its Epidemiology. Following a systematic literature search, relative risks (RRs) for sun exposure were extracted from 57 studies published before September 2002. Intermittent sun exposure and sunburn history were shown to play considerable roles as risk factors for melanoma, whereas a high occupational sun exposure seemed to be inversely associated to melanoma. The country of study and adjustment of the estimates adjuste for phenotype and photo-type were significantly associated with the variability of the intermittent sun exposure estimates (P = 0.024, 0.003 and 0.030, respectively). For chronic sun exposure, inclusion of controls with dermatological diseases and latitude resulted in significantly different data (P = 0.05 and 0.031, respectively). Latitude was also shown to be important (P = 0.031) for a history of sunburn; studies conducted at higher latitudes presented higher risks for a history of sunburns. Role of country, inclusion of controls with dermatological diseases and other study features seemed to suggest that "well conducted" studies supported the intermittent sun exposure hypothesis: a positive association for intermittent sun exposure and an inverse association with a high continuous pattern of sun exposure. |
| Databáze: | OpenAIRE |
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