Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy
| Autor: | Mihajlo Djokic, Bor Kos, Nina Boc, Maja Cemazar, Damijan Miklavčič, Maja Marolt Music, Ibrahim Edhemovic, Gregor Sersa, Masa Bosnjak, Erik Brecelj, Blaz Trotovsek |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Electrochemotherapy 0206 medical engineering R895-920 Contrast Media 02 engineering and technology Bleomycin Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine Electric field Antineoplastic Combined Chemotherapy Protocols Image Interpretation Computer-Assisted Hepatectomy Humans Medicine Effective treatment Radiology Nuclear Medicine and imaging treatment plan Radiation treatment planning Ultrasonography medicine.diagnostic_test ultrasound business.industry Liver Neoplasms Ultrasound Magnetic resonance imaging Middle Aged 020601 biomedical engineering electrochemotherapy Treatment Outcome colorectal liver metastases Oncology 030220 oncology & carcinogenesis Microbubbles Female Radiology Cisplatin Colorectal Neoplasms business Research Article Ablation zone |
| Zdroj: | Radiology and Oncology, Vol 52, Iss 4, Pp 383-391 (2018) Radiology and oncology (Ljubljana) Radiology and Oncology |
| ISSN: | 1581-3207 |
| Popis: | Background The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy of liver tumors to determine the actual ablation zone and to verify the coverage of the treated tumor with a sufficiently strong electric field for effective electrochemotherapy. Patients and methods US findings from two representative patients that describe immediate and delayed tumor changes after electrochemotherapy of colorectal liver metastases are presented. Results The US findings were interrelated with magnetic resonance imaging (MRI). Electrochemotherapy-treated tumors were exposed to electric pulses based on computational treatment planning. The US findings indicate immediate appearance of hyperechogenic microbubbles along the electrode tracks. Within minutes, the tumors became evenly hyperechogenic, and simultaneously, an oedematous rim was formed presenting as a hypoechogenic formation which persisted for several hours after treatment. The US findings overlapped with computed electric field distribution in the treated tissue, indicating adequate coverage of tumors with sufficiently strong electric field, which may predict an effective treatment outcome. Conclusions US provides a tool for assessment of appropriate electrode insertion for intraoperative electrochemo-therapy of liver tumors and assessment of the appropriate coverage of a tumor with a sufficiently strong electric field and can serve as predictor of the response of tumors. |
| Databáze: | OpenAIRE |
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