Effects of the antimalarial lumefantrine on Lemna minor, Raphidocelis subcapitata and Chlorella vulgaris
| Autor: | Hadiza Bashir, Jerry Tersoo Agee, Ramatu Idris Sha’aba, Abraham Gana Yisa, Ilu Ameh, Mathias Ahii Chia, Regina Anya Otogo, Ahmad Fatima Shaba, Ejiroghene Ebelechukwu Uyovbisere, Fatima Umar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chlorophyll
Health Toxicology and Mutagenesis Chlorella vulgaris Selenastrum 010501 environmental sciences Toxicology Lumefantrine 01 natural sciences Aquatic toxicology Antimalarials 03 medical and health sciences chemistry.chemical_compound Raphidocelis subcapitata Chlorophyta Malondialdehyde Aquatic plant Microalgae medicine Araceae Food science Artemether Glutathione Transferase Peroxidase Plant Proteins 030304 developmental biology 0105 earth and related environmental sciences Pharmacology 0303 health sciences Lemna minor biology Chemistry General Medicine biology.organism_classification Oxidative Stress Lipid Peroxidation Water Pollutants Chemical medicine.drug |
| Zdroj: | Environmental Toxicology and Pharmacology. 85:103635 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2021.103635 |
| Popis: | Lumefantrine is used to treat uncomplicated malaria caused by pure or mixed Plasmodium falciparum infections and as a prophylactic against recrudescence following artemether therapy. However, the pharmaceutical is released into the aquatic environment from industrial effluents, hospital discharges, and human excretion. This study assessed the effects of lumefantrine on the growth and physiological responses of the microalgae Chlorella vulgaris and Raphidocelis subcapitata (formerly known as Selenastrum capricornutum and Pseudokirchneriella subcapitata) and the aquatic macrophyte Lemna minor. The microalgae and macrophyte were exposed to 200-10000 μg l-1 and 16-10000 μg l-1 lumefantrine, respectively. Lumefantrine had a variable effect on the growth of the aquatic plants investigated. There was a decline in the growth of R. subcapitata and L. minor post-exposure to the drug. Contrarily, there was stimulation in the growth of Chlorella vulgaris. All experimental plants had a significant increase in lipid peroxidation, which was accompanied by an increase in malondialdehyde content. Peroxidase activity of L. minor increased only at low lumefantrine concentrations, while the opposite occurred at higher levels of the drug. Incubation in lumefantrine contaminated medium significantly up-regulated the activity of R. subcapitata cultures. Glutathione S-transferase of L. minor exposed to lumefantrine treatments had substantially higher activities than the controls. Our findings suggest lumefantrine could have adverse but variable effects on the growth and physiology of the studied aquatic plants. |
| Databáze: | OpenAIRE |
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