Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure
| Autor: | Kenneth Walsh, Yoshimitsu Yura, Soichi Sano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MPN myeloproliferative neoplasm lcsh:Diseases of the circulatory (Cardiovascular) system Il-1β inflammasome Somatic cell Cell Inflammation Disease 030204 cardiovascular system & hematology STATE-OF-THE-ART REVIEW PPM1D protein phosphatase Mg2+/Mn2+ dependent 1D 03 medical and health sciences TET2 ten-eleven translocation-2 0302 clinical medicine Immune system Medicine DNMT3A DNA methyltransferase-3A hsCRP high-sensitivity C-reactive protein TET2 TNF tumor necrosis factor business.industry fungi VAF variant allele fraction food and beverages HSPCs hematopoietic stem and progenitor cells medicine.disease Phenotype IL interleukin Haematopoiesis 030104 developmental biology medicine.anatomical_structure JAK2 lcsh:RC666-701 TNF-α Heart failure Immunology DNMT3A ASXL1 additional sex combs like 1 TP53 tumor protein 53 JAK2 janus kinase 2 medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 196-207 (2020) JACC: Basic to Translational Science |
| Popis: | Highlights • Clonal hematopoiesis is a common condition in the elderly that can result from the acquisition of somatic mutations in HSPCs that confer a selective advantage and allow for clonal cell expansion. • This clonal population of mutated HSPCs can give rise to leukocytes with altered immune properties, and this condition can adversely impact the cardiovascular system. • Clonal hematopoiesis may represent a new causal risk factor for cardiovascular disease that can add to the predictive value of the traditional risk factors. • Understanding the clonal hematopoiesis status of a patient could aid in the development of personalized strategies for anti-inflammatory therapies for cardiovascular disease. Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a process referred to as clonal hematopoiesis, has been reported to be associated with cardiovascular diseases including heart failure. Mechanistic studies have shown that leukocytes that harbor these somatic mutations display altered inflammatory characteristics that worsen the phenotypes associated with heart failure in experimental models. In this review, we summarize recent epidemiological and experimental evidence that support the hypothesis that clonal hematopoiesis-mediated immune cell dysfunction contributes to heart failure and cardiovascular disease in general. Central Illustration |
| Databáze: | OpenAIRE |
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