Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study
| Autor: | Takanao Hashimoto, Junichiro Hashimoto, Taku Obara, Yoko Aono, Azusa Hara, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Kazuhito Totsune, Yoriko Shintani, Kei Asayama, Haruhisa Hoshi, Takayoshi Ohkubo, Ryusuke Inoue, Hiroshi Satoh |
|---|---|
| Předmět: |
Male
medicine.medical_specialty Ambulatory blood pressure Physiology Population Blood Pressure Sensitivity and Specificity Internal medicine Internal Medicine medicine Prevalence Humans Circadian rhythm education Morning Aged Ultrasonography education.field_of_study business.industry Confounding Reproducibility of Results Arteriosclerosis Middle Aged medicine.disease Endocrinology Blood pressure Carotid Arteries Cross-Sectional Studies Ambulatory cardiovascular system Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | ResearcherID |
| Popis: | OBJECTIVES To investigate the association between ambulatory blood pressure (BP) variables (level, short-term variability, circadian variation and morning pressor surge) and carotid artery alteration in a general population. METHODS We measured ambulatory BP every 30 min in 775 participants (mean age 66.2 +/- 6.2 years, 68.8% women) from the Japanese general population. Short-term BP variability during the daytime and night-time were estimated as within-subject standard deviation of daytime and night-time BP, respectively. Circadian BP variation was calculated as the percentage decline in nocturnal BP. Morning pressor surge was defined as morning BP minus pre-waking BP. The extent of carotid artery alteration was evaluated as the average of common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. RESULTS Daytime and night-time BP values were more closely associated with carotid artery alteration than casual BP. With mutual adjustment for daytime and night-time BP, the latter (P < 0.0001) was more closely associated with IMT, which represents diffuse arterial thickening and arteriosclerosis, than daytime BP (P = 0.2). Night-time systolic BP variability was positively associated with carotid plaque (focal atherosclerotic lesions) independently of possible confounding factors, including night-time systolic BP (P = 0.01). A diminished nocturnal decline in systolic BP was associated with a greater IMT after adjustment for confounding factors (P = 0.03). A morning pressor surge was not associated with carotid artery alteration. CONCLUSION Ambulatory BP levels and BP variability were closely associated with carotid artery alteration, suggesting that these parameters are independent risk factors or predictors of carotid artery alteration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|