DNA damage, cell cycle perturbation and cell death by naphthalene diimide derivative in gastric cancer cells

Autor:	Sumiran Kumar Gurung, Sangeeta Kumari, Srikanta Dana, Kalyanashis Mandal, Sobhan Sen, Pritam Mukhopadhyay, Neelima Mondal
Rok vydání:	2021
Předmět:	Stomach Neoplasms Cell Line Tumor Cell Cycle Humans Apoptosis General Medicine Naphthalenes Toxicology Imides beta Catenin DNA Damage
Zdroj:	Chemico-biological interactions. 358
ISSN:	1872-7786
Popis:	Stomach cancer causes the third-highest cancer-related deaths worldwide. Limited availability of anticancer measures with higher efficiency and low unwanted toxicities necessitates the development of better cancer chemotherapeutics. Naphthalene diimide (NDI) derivatives have gained significant attention owing to their excellent anticancer potential. We evaluated the anticancer properties of NDI derivatives, 1a and 2a in cancer cell lines and found that 1a showed higher efficacy as compared to 2a exhibiting a remarkable difference in activity upon single atom substitution of C with N. Particularly, NDI 1a showed potent inhibitory activity against gastric cancer cell line AGS with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa32b0eba9316121bfcabc81cf8bcd8 https://pubmed.ncbi.nlm.nih.gov/35307378 Zobrazit plný text záznamu Full Text from ScienceDirect