Contact Lens Versus Non-Contact Lens-Related Corneal Ulcers at an Academic Center
| Autor: | Hugo Y. Hsu, Benjamin J. Ernst, Lisa Bennett, Shannon Tai, Sean L. Edelstein, Chelsea Horwood, Eric J. Schmidt, Rohit Parihar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Contact Lenses Antiprotozoal Agents Eye Infections Bacterial 03 medical and health sciences 0302 clinical medicine Ophthalmology Medicine Humans 030212 general & internal medicine Eye Infections Parasitic Child Corneal Ulcer Aged Retrospective Studies Aged 80 and over Retrospective review Academic Medical Centers business.industry Infant Retrospective cohort study Eye infection Middle Aged corneal ulcer medicine.disease humanities Anti-Bacterial Agents Contact lens Acanthamoeba Keratitis Child Preschool 030221 ophthalmology & optometry Female sense organs business Eye Infections Fungal |
| Zdroj: | Eyecontact lens. 45(5) |
| ISSN: | 1542-233X |
| Popis: | To compare the infectious contact lens-related corneal ulcer (CLRU) and non-CLRU cases at Saint Louis University.Retrospective review of corneal ulcer cases identified by search of the ophthalmology and microbiology department databases between 1999 and 2016.Six hundred seventy-seven cases of corneal ulcers were identified, of which 46% were CLRU. CLRU cases were seen more commonly in younger patients (P0.001) and women (P=0.03) than non-CLRU cases. Many of the infections were vision-threatening as defined by central/paracentral location (73% CLRU and 71% non-CLRU [P=0.60]) and large size of ulcer2 mm in 36% CLRU and 51% non-CLRU (P=0.002). Causative pathogen in cultured CLRU was predominately Pseudomonas species (44%, P0.001 vs. the non-CLRU group), other gram-negative (6%), gram-positive (33%), fungi (13%), and Acanthamoeba (5%). Comparatively, cultured non-CLRU was predominately gram-positive (64%, P0.001 vs. the CLRU group), gram-negative (26%), and fungi (11%). The combined oxacillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus isolates were 35% and 34%, respectively. Despite the progressive increase in the number of corneal ulcers seen, the annual trend for any one particular organism for either CLRU cases or non-CLRU cases did not change significantly.Most of the cases were non-CLRU. CLRU was disproportionately associated with Pseudomonas species and non-CLRU with Staphylococcal species. Fungal infections were predominately caused by filamentous organisms in both groups. Acanthamoeba keratitis was exclusively associated with CL use. |
| Databáze: | OpenAIRE |
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