Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma
| Autor: | Toshio Numao, Naoto Fueki, Takeshi Fukuda, Naoto Watanabe, Alexander Tsodikov, Guy A. Zimmerman, Sohei Makino, Stephen M. Prescott, Diana M. Stafforini, Darius Vaitkus, Thomas M. McIntyre |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathophysiology of asthma PAF acetylhydrolase Adolescent Genotype Molecular Sequence Data Severity factor Biology Article Phospholipases A Proinflammatory cytokine Japan PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE medicine Humans Missense mutation Amino Acid Sequence Child Aged Asthma Binding Sites Polymorphism Genetic Base Sequence Homozygote Airway inflammation General Medicine Middle Aged respiratory system medicine.disease respiratory tract diseases 1-Alkyl-2-acetylglycerophosphocholine Esterase Mutation Immunology Female lipids (amino acids peptides and proteins) |
| Zdroj: | Journal of Clinical Investigation. 103:989-997 |
| ISSN: | 0021-9738 |
| Popis: | Asthma, a family of airway disorders characterized by airway inflammation, has an increasing incidence worldwide. Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma. Its proinflammatory actions are antagonized by PAF acetylhydrolase. A missense mutation (V279F) in the PAF acetylhydrolase gene results in the complete loss of activity, which occurs in 4% of the Japanese population. We asked if PAF acetylhydrolase deficiency correlates with the incidence and severity of asthma in Japan. We found that the prevalence of PAF acetylhydrolase deficiency is higher in Japanese asthmatics than healthy subjects and that the severity of this syndrome is highest in homozygous-deficient subjects. We conclude that the PAF acetylhydrolase gene is a modulating locus for the severity of asthma. |
| Databáze: | OpenAIRE |
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