Biological activities of oligoketide pigments of Monascus purpureus
| Autor: | J Ulrichová, Ludmila Martínková, B Ríhová, O Hovorka, Petr Olšovský, D Veselý, P Patáková-Jůzlová, V. Prikrylova, V Krent, Z Kucerová, Vladimír Havlíček, D Veselá |
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| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Health Toxicology and Mutagenesis T-Lymphocytes Bacillus subtilis Chick Embryo Toxicology Mass Spectrometry Mice Column chromatography Ascomycota Immune Tolerance Moiety Animals Monascus purpureus Mycelium Antibacterial agent Candida biology Cell Death Public Health Environmental and Occupational Health Abnormalities Drug-Induced Food Coloring Agents Biological activity General Chemistry Pigments Biological biology.organism_classification Rats Biochemistry Chemistry (miscellaneous) Glycine Hepatocytes Food Science |
| Zdroj: | Food additives and contaminants. 16(1) |
| ISSN: | 0265-203X |
| Popis: | Rubropunctatin (1), monascorubrin (2), monascin (3) and ankaflavin (4) were purified from the mycelium of Monascus purpureus by flash chromatography on silica gel or reversed phase. Their embryotoxicity towards chicken embryos decreased in the order 2 > 1 > 3 > 4. The lower homologues 1 and 3 exhibited teratogenic effects on these organisms. Significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis were found with compounds 1 and 2. Immunosuppressive activity on mouse T-splenocytes was most pronounced with compounds 3 and 4. None of the compounds showed significant cytotoxic activity towards rat hepatocytes in vitro. Incubation of resting cells of M. purpureus with glycine afforded the dark-red compounds 5 and 6 where the pyran moiety of 1 and 2 changed into the N-substituted dihydropyridine moiety by replacement of the O-atom by the amino group of glycine. Compounds 5 and 6 were less biologically active than the major pigments 1-4. |
| Databáze: | OpenAIRE |
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