Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
| Autor: | Jan M. Deussing, Claudia Kühne, Daniel J. Spergel, Diego García-González, Androniki Raftogianni, Lena C. Roth, Thorsten Bus, Valery Grinevich, Hannah Monyer |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system Central nervous system Hypothalamic–pituitary–gonadal axis Biology Gonadotropic cell lcsh:RC321-571 reproduction 03 medical and health sciences Cellular and Molecular Neuroscience stress 0302 clinical medicine gonadotropes Internal medicine medicine Receptor Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research Luteinizing hormone secretion CRH receptors 030104 developmental biology Endocrinology medicine.anatomical_structure GnRH neurons nervous system CRH GnRH GABAergic Luteinizing hormone 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Hormone Neuroscience |
| Zdroj: | Frontiers in Molecular Neuroscience, Vol 11 (2018) Frontiers in Molecular Neuroscience FRONTIERS IN MOLECULAR NEUROSCIENCE |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2018.00305/full |
| Popis: | Based on pharmacological studies, corticotropin-releasing hormone (CRH) and its receptors play a leading role in the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis during acute stress. To further study the effects of CRH receptor signaling on the HPG axis, we generated and/or employed male mice lacking CRH receptor type 1 (CRHR1) or type 2 (CRHR2) in gonadotropin-releasing hormone neurons, GABAergic neurons, or in all central neurons and glia. The deletion of CRHRs revealed a preserved decrease of plasma luteinizing hormone (LH) in response to either psychophysical or immunological stress. However, under basal conditions, central infusion of CRH into mice lacking CRHR1 in all central neurons and glia, or application of CRH to pituitary cultures from mice lacking CRHR2, failed to suppress LH release, unlike in controls. Our results, taken together with those of the earlier pharmacological studies, suggest that inhibition of the male HPG axis during acute stress is mediated by other factors along with CRH, and that CRH suppresses the HPG axis at the central and pituitary levels via CRHR1 and CRHR2, respectively. |
| Databáze: | OpenAIRE |
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