Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii

Autor:	Pen-Ho Yeh, Chia-Ching Liaw, Yun-Dar Shieh, Li-Ming Yang Kuo, Yao-Haur Kuo, Jhih-Hu Lin, Li-Chun Hsu
Jazyk:	angličtina
Předmět:	Biflavonoids biology Stereochemistry Topoisomerase Cytotoxicity lcsh:R lcsh:Medicine Apoptosis Fractionation biology.organism_classification Podocarpus nakaii Topoisomerase I Complementary and alternative medicine Botany biology.protein Cytotoxic T cell Original Article [3′→8″]-Biflavonoids ED50
Zdroj:	Journal of Traditional and Complementary Medicine Journal of Traditional and Complementary Medicine, Vol 2, Iss 3, Pp 220-226 (2012)
ISSN:	2225-4110
DOI:	10.1016/S2225-4110(16)30103-1
Popis:	Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′ → 8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as 1H, 13C, 1H-1H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
Databáze:	OpenAIRE
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