Tissue tolerance to cyanoacrylate adhesives for closure of surgical wounds in Trachemys scripta skin
| Autor: | Pedro J. Ginel, Rafael Guerra, Sayda Pérez‐Delgado, V. Molina, Elena Mozos, Rosario Lucena |
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| Rok vydání: | 2020 |
| Předmět: |
Dorsum
medicine.medical_specialty 040301 veterinary sciences Surgical Wound Dehiscence law.invention 0403 veterinary science law medicine Animals Cyanoacrylates High rate integumentary system General Veterinary Wound dehiscence business.industry 0402 animal and dairy science Surgical wound 04 agricultural and veterinary sciences General Medicine medicine.disease 040201 dairy & animal science Surgery Turtles Trachemys scripta Treatment Outcome Cyanoacrylate Female Tissue Adhesives Wound healing business |
| Zdroj: | The Veterinary recordREFERENCES. 188(5) |
| ISSN: | 2042-7670 |
| Popis: | Background The aim of this study was to evaluate the histological tolerance of medical cyanoacrylate adhesives (CAs), butyl-CA and octyl-CA, applied by two different methods in surgical skin incisions of T. scripta. Methods A two-trial controlled blind study each one including 12 female adult T. scripta turtles. Two 1-cm long full-thickness surgical skin incisions were made on the dorsal aspect of each hind limb. In trial 1 CAs were applied superficially over the apposed wound edges; each animal's four wounds were closed using butyl-CA, octyl-CA and ethyl-CA or absorbable suture as controls. In trial 2 adhesives were applied holding wound edges everted, and octyl-CA was replaced by a non-sutured control wound. At each time point (2, 7, 14 and 21 days) all wounds from three randomly chosen animals were biopsied. Results Medical grade CAs did not induce any sign of tissue damage and/or inflammatory reaction attributable to histotoxicity independently of the method of application. Wound dehiscence rate was higher when CAs were applied superficially over the apposed wound edges. Conclusions Octyl and butyl-CA are well tolerated by turtles' soft skin but because of their high rate of dehiscence they are not recommended in high tension wounds; use in low tension wounds needs further investigation. |
| Databáze: | OpenAIRE |
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