One-week triple regime therapy consisting of pantoprazole, amoxicillin and clarithromycin for cure of Helicobacter pylori-associated upper gastrointestinal diseases
| Autor: | S. Nayal, Asad Dajani, G Abdul Aal, Z. Abdul Rasheed, S. Ukabam, S. Awad, M. Nounou, S. Gautam |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Gastrointestinal Diseases Biopsy Colony Count Microbial Proton-pump inhibitor Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Helicobacter Infections Pharmacotherapy Internal medicine Clarithromycin polycyclic compounds medicine Humans Endoscopy Digestive System Intestinal Mucosa Pantoprazole Antibacterial agent biology Helicobacter pylori business.industry Amoxicillin bacterial infections and mycoses biology.organism_classification Anti-Ulcer Agents Treatment Outcome Sulfoxides Benzimidazoles Drug Therapy Combination Female Gastritis medicine.symptom business Omeprazole medicine.drug Follow-Up Studies |
| Zdroj: | Digestion. 60(3) |
| ISSN: | 0012-2823 |
| Popis: | This study was designed to determine the efficacy and safety of 1-week triple therapy regime consisting of pantoprazole, amoxicillin and clarithromycin in the cure of Helicobacter pylori infection leading to duodenal ulcer disease and/or gastritis. Sixty-one patients (47 males, 14 females with a mean age of 34 years) belonging to different ethnic groups suffering from H. pylori-associated duodenal ulcer and/or gastritis for an average of 2.46 years were recruited. Having satisfied primary selection criteria, patients received pantoprazole 40 mg b.i.d., clarithromycin 500 mg b.i.d. and amoxicillin 1,000 mg b.i.d. for 7 days. All medications were stopped there after H. pylori eradication was determined 4–6 weeks after treatment by a repeat endoscopy, a rapid urease test, H. pylori culture and histology assessment as indicators of cure. All three tests must be negative to consider the infection to have been successfully eradicated. Fifty-seven patients completed the efficacy analysis per protocol. Dramatic symptomatic improvement was noted in most patients immediately after stopping treatment and it was sustained at 6 weeks. At the end of the study, the healing rate of duodenal ulcers (complete re-epithelialization) following 1-week treatment only, as indicated above, and without any maintenance therapy was 66.7%, that of gastritis was 55.7%, and that of erosions was 64.3%. The overall eradication rate for H. pylori, however, was 93% (95% CI 83.0–98.1%). Furthermore, histologic evaluation revealed a remarkable resolution in the activity of gastritis in all the patients who had successful eradication of the infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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