Relationship between hyposalivation and oxidative stress in aging mice
| Autor: | Kazuhiko Omata, Tazuko Satoh, Tomonori Matsuno, Yoshitaka Yamauchi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Saliva Clinical Biochemistry Saliva secretion Medicine (miscellaneous) salivary gland medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Atrophy stomatognathic system Fibrosis Internal medicine Parenchyma medicine oxidative stress hyposalivation Nutrition and Dietetics Salivary gland business.industry aging 030206 dentistry medicine.disease Submandibular gland stomatognathic diseases 030104 developmental biology Endocrinology medicine.anatomical_structure Original Article business Oxidative stress |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.16-79 |
| Popis: | The increase in oxidative stress that accompanies aging has been implicated in the abnormal advance of aging and in the onset of various systemic diseases. However, the details of what effects the increase in oxidative stress that accompanies aging has on saliva secretion are not known. In this study, naturally aging mice were used to examine the stimulated whole saliva flow rate, saliva and serum oxidative stress, antioxidant level, submandibular gland H-E staining, and immunofluorescence staining to investigate the effect of aging on the volume of saliva secretion and the relationship with oxidative stress, as well as the effect of aging on the structure of salivary gland tissue. The stimulated whole saliva flow rate decreased significantly with age. Also, oxidative stress increased significantly with age. Antioxidant levels, however, decreased significantly with age. Structural changes of the submandibular gland accompanying aging included atrophy of parenchyma cells and fatty degeneration and fibrosis of stroma, and the submandibular gland weight ratio decreased. These results suggest that oxidative stress increases with age, not just systemically but also locally in the submandibular gland, and that oxidative stress causes changes in the structure of the salivary gland and is involved in hyposalivation. |
| Databáze: | OpenAIRE |
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