ENZYMATIC PREPARATION OF HOMOCHIRAL 2-(N-CARBOBENZYLOXYPIPERID-4-YL)-1,3-PROPANEDIOL MONOACETATE - A FACILE ENTRY TO BOTH ENANTIOMERS OF 3-HYDROXYMETHYLQUINUCLIDINE

Autor:	Luca Banfi, E. Narisano, Stefano Brusco, Giuseppe Guanti
Jazyk:	angličtina
Rok vydání:	1994
Předmět:	biology Bicyclic molecule Organic Chemistry Diol Triacylglycerol lipase Catalysis Inorganic Chemistry Acylation chemistry.chemical_compound chemistry biology.protein Organic chemistry 1 3-Propanediol Physical and Theoretical Chemistry Enantiomer Lipase Aliphatic compound
Popis:	Both enantiomers of monoacetate 1 have been prepared in high ee by lipase catalyzed monohydrolysis of the prochiral diacetate 3 and by monoacetylation of the corresponding diol 4.3-Hydroxymethylquinuclidine 2 was then synthesized in both enantiomeric forms with an ee up to 98% starting from (+)- 1 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f98cdc06ccbb6d4c8f4dee832e832f7 https://hdl.handle.net/11567/1111063 Zobrazit plný text záznamu