Neuronal regulation of intestinal immune functions in health and disease
| Autor: | W J de Jonge, Matteo Fornai, Corrado Blandizzi, Carolina Pellegrini, R.M.J.G.J. van den Wijngaard, Luca Antonioli |
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| Přispěvatelé: | Tytgat Institute for Liver and Intestinal Research, AGEM - Re-generation and cancer of the digestive system, AGEM - Digestive immunity, Gastroenterology and Hepatology, ANS - Neuroinfection & -inflammation, AII - Inflammatory diseases |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology Gastrointestinal Diseases Neuroimmunomodulation Disease Enteric mucosal immune system Enteric Nervous System 03 medical and health sciences Immune system Autonomic nervous system Inflammatory bowel disorders Intestinal epithelium Mucosal permeability Endocrine and Autonomic Systems Gastroenterology medicine Animals Humans Intestinal Mucosa Autonomic nerve business.industry medicine.disease Epithelium Gastrointestinal Tract 030104 developmental biology medicine.anatomical_structure Gastrointestinal disease business Neuroscience Function (biology) |
| Zdroj: | Neurogastroenterology and motility, 30(12). Wiley-Blackwell |
| ISSN: | 1365-2982 1350-1925 |
| Popis: | Background Nerve-mucosa interactions control various elements of gastrointestinal functions, including mucosal host defense, gut barrier function, and epithelial cell growth and differentiation. In both intestinal and extra-intestinal diseases, alterations of autonomic nerve activity have been observed to be concurrent with the disease course, such as in inflammatory and functional bowel diseases, and neurodegenerative diseases. This is relevant as the extrinsic autonomic nervous system is increasingly recognized to modulate gut inflammatory responses. The molecular and cellular mechanisms through which the extrinsic and intrinsic nerve pathways may regulate digestive mucosal functions have been investigated in several pre-clinical and clinical studies. Purpose The present review focuses on the involvement of neural pathways in gastrointestinal disease, and addresses the current strategies to intervene with neuronal pathway as a means of treatment. |
| Databáze: | OpenAIRE |
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