Recombinant bone morphogenetic protein-2 and platelet-derived growth factor-BB for localized bone regeneration. Histologic and radiographic outcomes of a rabbit study
| Autor: | Ui Won Jung, Hyun Chang Lim, Daniel S. Thoma, Ronald E. Jung, So-Ra Yoon, Vitor Marques Sapata |
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| Přispěvatelé: | University of Zurich, Jung, Ui-Won |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Bone Regeneration Recombinant bone morphogenetic protein 2 Radiography medicine.medical_treatment 0206 medical engineering Becaplermin Bone Morphogenetic Protein 2 610 Medicine & health 02 engineering and technology Group comparison Bone morphogenetic protein 2 Parietal Bone 10068 Clinic of Reconstructive Dentistry 03 medical and health sciences 0302 clinical medicine medicine Animals Bone regeneration biology 3504 Oral Surgery business.industry Growth factor Histology Proto-Oncogene Proteins c-sis X-Ray Microtomography 030206 dentistry 020601 biomedical engineering Recombinant Proteins Frontal Bone biology.protein Rabbits Oral Surgery business Platelet-derived growth factor receptor |
| DOI: | 10.5167/uzh-136337 |
| Popis: | OBJECTIVES: Improvement in localized bone regeneration is needed to avoid the use of autogenous tissue. For that purpose, the use biologic mediators was proposed. The aim was to test whether or not one of two biologic mediators, recombinant human bone morphogenetic protein-2 (rhBMP-2) or recombinant platelet-derived growth factor (rhPDGF-BB), is superior to the other and to control groups for localized bone regeneration. MATERIALS AND METHODS: Four cylinders (height: 5 mm; diameter: 7 mm) were screwed on the parietal and frontal bones at the cranium in 12 rabbits. The cylinders either received (i) deproteinized bovine bone mineral (DBBM) mixed rhBMP-2 (DBBM/BMP-2), (ii) DBBM mixed with rhPDGF-BB (DBBM/PDGF), (iii) DBBM (DBBM), and (iv) empty control (control). Rabbits were euthanized at 2 and 8 weeks (n = 6, respectively). Conventional histomorphometric and micro-CT analyses were performed. Parametric linear mixed models were applied for the analyses with Bonferroni correction for the multiple group comparisons. RESULTS: The area of bone regeneration (histology; AAHisto ) at 2 weeks peaked for DBBM (41.91%) with statistically significantly greater values compared to DBBM/PDGF and the control group (P 0.05). CONCLUSIONS: The use of rhBMP-2 significantly enhanced bone regeneration compared to all other groups including the group with rhPDGF-BB. |
| Databáze: | OpenAIRE |
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