Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice
| Autor: | Tracy L. Walling, David M. Foureau, Ashley L. Eheim, Laura W. Schrum, Iain H. McKillop, Elizabeth Brandon-Warner |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research Alcoholic liver disease medicine.medical_specialty Carcinoma Hepatocellular Alcohol Drinking Silibinin Pharmacology medicine.disease_cause Antioxidants Article Silybum marianum Mice chemistry.chemical_compound In vivo Internal medicine Animals Milk Thistle Medicine Ethanol metabolism Cell Proliferation Sex Characteristics Ethanol biology business.industry Liver Neoplasms biology.organism_classification medicine.disease digestive system diseases Tumor Burden Endocrinology Oncology chemistry Silybin Hepatocellular carcinoma Dietary Supplements Disease Progression Female business Oxidative stress Silymarin |
| Zdroj: | Cancer Letters. 326:88-95 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2012.07.028 |
| Popis: | Hepatocellular carcinoma (HCC) is a global health burden with limited treatment options and poor prognosis. Silibinin, an antioxidant derived from the Milk Thistle plant (Silybum marianum), is reported to exert hepatoprotective and antitumorigenic effects in vitro and in vivo by suppressing oxidative stress and proliferation. Using a DEN-initiated mouse model of HCC, this study examined the effects of dietary silibinin supplementation alone, or in combination with chronic ethanol consumption on HCC progression. Our data demonstrate silibinin exerted marginal hepatoprotective effects in early stages of hepatocarcinogenesis but, when co-administered with ethanol, exacerbated the promotional effects of ethanol in HCC bearing mice, but only in males. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect