Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations
| Autor: | Ilene Fennoy, Rudy Leibel, Marisa Censani, Liyong Deng, Jeffrey L. Zitsman, Sharon E. Oberfield, Wendy K. Chung, Donald J. McMahon, Rushika Conroy |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) MC4R Morbidly obese Adolescents Article Body Mass Index Endocrinology Weight loss Weight Loss Humans Medicine In patient Prospective Studies Obesity Prospective cohort study Postoperative Care Bariatric surgery Nutrition and Dietetics business.industry Sequence Analysis DNA Obesity Morbid Surgery Mutation Mutation (genetic algorithm) Receptor Melanocortin Type 4 Female medicine.symptom business Body mass index |
| Zdroj: | Obesity (Silver Spring, Md.) |
| ISSN: | 1930-739X 1930-7381 |
| DOI: | 10.1002/oby.20511 |
| Popis: | Objective To determine the frequency of Melanocortin4 Receptor (MC4R) mutations in morbidly obese adolescents undergoing bariatric surgery and compare weight loss outcomes in patients with and without mutations. Design and Methods In this prospective cohort study, 135 adolescent patients evaluated for bariatric surgery were screened for MC4R mutations; 56 had 12 month postoperative data available for analysis. Results MC4R mutations were detected in five of the 135 patients (3.7%); four underwent restrictive bariatric surgery. For the three patients with gastric banding, percent excess weight loss (%EWL) postoperatively was 36.0% at 5 years in one, 47% at 4 years in the second, and 85% at 1 year in the third. For the patient with gastric sleeve resection, %EWL of 96% was attained at 1 year postoperatively. The four MC4R cases had a higher, although non-significant, %EWL compared to 52 non-matched controls at 12 months postoperatively (48.6% vs. 23.4%; p |
| Databáze: | OpenAIRE |
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