First Class of Phosphorus Dendritic Compounds Containing β-Cyclodextrin Units in the Periphery Prepared by CuAAC
| Autor: | Ernesto Rivera, Anne-Marie Caminade, Kendra Sorroza-Martínez, Javier Illescas, Israel González-Méndez, Mireille Vonlanthen, Kathleen I. Moineau-Chane Ching |
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| Přispěvatelé: | Instituto de Investigaciones en Materiales (Mexico, Mexico), Universidad Nacional Autónoma de México (UNAM), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Tecnológico Nacional de México (TecNM), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Quebec-Mexico Bilateral Research Program from FQRNT (Fonds québécois de la recherche sur la nature et les technologies) of Quebec, CONACYT of Mexico (Project 279380) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Dendrimers
Magnetic Resonance Spectroscopy Pharmaceutical Science chemistry.chemical_element Phosphorus dendritic compounds 010402 general chemistry Ring (chemistry) 01 natural sciences Article Catalysis Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Polymer chemistry [CHIM.COOR]Chemical Sciences/Coordination chemistry Physical and Theoretical Chemistry CuAAC reaction chemistry.chemical_classification Aqueous solution Cycloaddition Reaction Cyclodextrin 010405 organic chemistry Phosphorus beta-Cyclodextrins Organic Chemistry Water hemic and immune systems Copper Cycloaddition 3. Good health 0104 chemical sciences Solubility chemistry Chemistry (miscellaneous) β-cyclodextrin Molecular Medicine Protons Drug carrier |
| Zdroj: | Molecules Molecules, MDPI, 2020, 25 (18), pp.4034. ⟨10.3390/molecules25184034⟩ Volume 25 Issue 18 Molecules, Vol 25, Iss 4034, p 4034 (2020) Molecules, 2020, 25 (18), pp.4034. ⟨10.3390/molecules25184034⟩ |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25184034⟩ |
| Popis: | A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (P3N3) core and decorated with six &beta cyclodextrin (&beta CD) units, named P3N3-[O-C6H4-O-(CH2)n-&beta CD]6, where n = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the P3N3, two linkers consisting of an aromatic ring and an aliphatic chain of two different lengths were assessed. We found that, with both linkers, the total modification of the periphery was achieved. The two new obtained dendritic compounds presented a considerably high water solubility (> 1 g/mL). The compounds comprised in this new class of PDCs are potential drug carrier candidates, since the conjugation of the &beta CD units to the P3N3 core through the primary face will not only serve as surface cover but, also, provide them the faculty to encapsulate various drugs inside the &beta CDs cavities. |
| Databáze: | OpenAIRE |
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