Assisted reproductive technology (ART) cumulative live birth rates following preimplantation genetic diagnosis for aneuploidy (PGD-A) or morphological assessment of embryos: A cohort analysis

Autor: Lyndon Hale, Georgina M. Chambers, P. J. Illingworth, Leeanda Wilton, Evelyn Lee
Rok vydání: 2017
Předmět:
Zdroj: Australian and New Zealand Journal of Obstetrics and Gynaecology. 58:525-532
ISSN: 0004-8666
DOI: 10.1111/ajo.12756
Popis: Background Preimplantation genetic diagnosis for aneuploidy (PGD-A) for all 24 chromosomes improves implantation and clinical pregnancy rates per single assisted reproductive technology (ART) cycle. However, there is limited data on the live-birth rate of PGD-A over repeated cycles. Aim To assess the cumulative live-birth rates (CLBR) of PGD-A compared with morphological assessment of embryos of up to three ‘complete ART cycles’ (fresh plus frozen/thaw cycles) in women aged 37 years or older. Materials and Methods A retrospective cohort study of ART treatments undertaken by ART-naive women at a large Australian fertility clinic between 2011 and 2014. Cohorts were assigned based on the embryo selection method used in their first fresh cycle [PGD-A, n = 110 women (PGD-A group); morphological assessment of embryos, n = 1983 women (control group)]. CLBR, time to clinical pregnancy and cycles needed to achieve a live birth were measured over multiple cycles. Results Compared to the control group, the PGD-A group achieved a higher per cycle live-birth rate (14.47% vs 9.12%, P
Databáze: OpenAIRE
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