TGF-β1 Gene Polymorphisms and Peritoneal Equilibration Test Results in CAPD Patients

Autor:	Sukru Sindel, Sevim Gönen, Musa Bali, Ulver Derici, Yasemin Erten, Kadriye Altok Reis, Turgay Arinsoy, Fatma Ayerden Ebinç
Rok vydání:	2008
Předmět:	Adult Male medicine.medical_specialty Genotype medicine.medical_treatment Peritoneal equilibration test Critical Care and Intensive Care Medicine Peritoneal dialysis Transforming Growth Factor beta1 Peritoneal Dialysis Continuous Ambulatory Polymorphism (computer science) Internal medicine Humans Medicine Peritoneal Fibrosis Aged chemistry.chemical_classification Polymorphism Genetic business.industry Biological Transport General Medicine Middle Aged Genotype frequency Amino acid Endocrinology Amino Acid Substitution chemistry Nephrology Female Gene polymorphism Peritoneum business
Zdroj:	Renal Failure. 30:15-19
ISSN:	1525-6049 0886-022X
Popis:	Transforming growth factor-beta-1 (TGF-1) stimulates the expression of collagen mRNA in cultured human peritoneal mesangial cells, which may predispose them to developing peritoneal fibrosis. Polymorphisms in the signal sequence genetically may be responsible for increased TGF-beta 1 production (i.e., a substitution at amino acid position 10 and 25, +869 Leu(10)-Pro and +915 Arg(25)-Pro, respectively). The aim of this study was to find out whether there is any relation between peritoneal equilibration test (PET) results and TGF-1 gene polymorphism. Thirty-two CAPD patients and 72 healthy subjects were included into the study. Each CAPD patient had undergone two PET with a two-year interval. The patients were classified according to the results of a baseline PET as high (high-high average) and low (low-low average) transporters. In high transporters group (n = 20), the genotype frequencies were found as 45% Leu/Leu, 55% Leu/Pro for codon 10; and 85% Arg/Arg, 15% Arg/Pro for codon 25. In low transporters group (n = 12), the genotype frequencies were detected as 66.7% Leu/Leu and 33.3% Leu/Pro for codon 10; and 83.3% Arg/Arg, 16.7% Arg/Pro for codon 25. The distribution of the TGF-beta 1 genotypes in our control population was compatible with a Hardy-Weinberg equilibrium. We found no relation between TGF-beta 1 genotypes and peritoneal transport group (chi(2) test, p > 0.5). There was no relation between TGF-beta 1 genotype and longitudinal change in peritoneal transport. This study is the first study analyzing the possible link between TGF-beta 1 gene polymorphisms and the characteristics of peritoneal transport and longitudinal change of peritoneal transport characteristics in CAPD patients. Further work is needed to clarify the functional importance of these two polymorphisms in TGF-beta 1 production and in the development of peritoneal fibrosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9058bf0b2fe3a2c8fdd423d7fbb416 https://doi.org/10.1080/08860220701741684 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.