Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis
| Autor: | Ricardo Simoes, Danilo Sales Bocalini, Stella S. Vieira, Eduardo Carvalho de Arruda Veiga, Brunno Lemes de Melo, Edmund Chada Baracat, Vitor Engrácia Valenti, Julien S. Baker, José Maria Soares-Júnior, Roberta Lukesvicius Rica, Joseane Elza Tonussi Mendez Rossetti do Vale, Andrey Jorge Serra, Marcelo Ferraz Campos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty Medicine (General) Systematic Reviews Heart Ventricles MEDLINE Myocardial Infarction Infarction Review Article 030204 cardiovascular system & hematology Running Rats Sprague-Dawley 03 medical and health sciences Mice 0302 clinical medicine R5-920 Internal medicine Physical Conditioning Animal medicine Animals Ventricular Function Experimental Myocardial Infarctions 030212 general & internal medicine Myocardial infarction Prior Exercise Exercise Training Rats Wistar Swimming Ejection fraction business.industry Models Cardiovascular Heart General Medicine medicine.disease Rats Disease Models Animal medicine.anatomical_structure Systematic review Ventricle Meta-analysis Cardiology cardiovascular system Female business Meta-Analysis |
| Zdroj: | Clinics, Volume: 75, Article number: e1293, Published: 20 JAN 2020 Clinics Clinics; v. 75 (2020); e1293 Clinics; Vol. 75 (2020); e1293 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results - Mean difference 95% CI - -0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals -5.05 [-7.68, -2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals. |
| Databáze: | OpenAIRE |
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