The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review
| Autor: | Jolien Schol, Emidio Scarpellini, Karen Van den Houte, Florencia Carbone, Wout Verbeure, Hideki Mori, Imke Masuy, Jan Tack |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
gastroparesis lcsh:RC435-571 Motilin receptor Peptide hormone Gastroenterology Motilin 03 medical and health sciences 0302 clinical medicine QUALITY-OF-LIFE Internal medicine lcsh:Psychiatry glucagonlike peptide 1 peptide YY Medicine Gastroparesis PLASMA GHRELIN LEVELS GASTRIC SENSORIMOTOR FUNCTION Cholecystokinin Psychiatry Science & Technology Gastric emptying TYPE-1 DIABETES-MELLITUS business.industry motilin digestive oral and skin physiology MOTILIN RECEPTOR AGONIST medicine.disease MEAL-RELATED SYMPTOMS functional dyspepsia GRANISETRON TRANSDERMAL SYSTEM 030227 psychiatry cholecystokinin RANDOMIZED CLINICAL-TRIAL Psychiatry and Mental health gastrointestinal peptides Peptide YY ghrelin Ghrelin Systematic Review MIGRATING MOTOR COMPLEX business Life Sciences & Biomedicine CRITICALLY-ILL PATIENTS 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Frontiers in Psychiatry, Vol 11 (2020) Frontiers in Psychiatry |
| ISSN: | 1664-0640 |
| DOI: | 10.3389/fpsyt.2020.00172/full |
| Popis: | Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition have been identified as putative underlying mechanisms. Motility, sensitivity as well as responses to nutrition can be influenced or mediated by peptide hormones and serotonin released from the gastrointestinal mucosa. This review summarizes the role of GI peptides in functional dyspepsia and gastroparesis. In most studies, the levels of somatostatin, ghrelin, and motilin did not differ between healthy volunteers and FD or GP patients, but higher symptom burden was often correlated with higher peptide levels. Ghrelin and motilin receptor agonists showed promising results in improvement of the gastric emptying, but the link with improvement of symptoms is less predictable. Serotonin agonists have a potential to improve symptoms in both FD and idiopathic gastroparesis. Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation. There is a need for systematic large scale studies. ispartof: FRONTIERS IN PSYCHIATRY vol:11 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|