Pigeon breeder's lung: association with HLA-DR 3
| Autor: | E. Mollenhauer, M. Lüttkenhorst, N. Rösinger, M. P. Baur, Ch. Rittner, I. Stroehmann, J. Sennekamp, D. Niese |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Linkage disequilibrium Genes MHC Class II Immunology Biology Biochemistry Asymptomatic Complement factor B Bird Fancier's Lung Gene Frequency HLA Antigens Internal medicine Genetics medicine HLA-DR Humans Immunology and Allergy Lung Complement C4 Complement C3 General Medicine Serum concentration Allotype medicine.anatomical_structure Endocrinology medicine.symptom Alveolitis Extrinsic Allergic |
| Zdroj: | Tissue Antigens. 21:374-379 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1983.tb00186.x |
| Popis: | 52 symptomatic (SPB) and 64 asymptomatic (APB) pigeon breeders were investigated for the HLA-A, -B, -C, -DR; C2, C3, C4 and Bf systems, and C3, C4 and factor B serum concentrations. HLA-DR3 and Bf S frequencies were significantly higher in the SPB than the APB group. Mean factor B concentrations were lower in the SPB than in the APB group. A positive two-way association between HLA-DR3 and the disease was found. It is concluded that a gene or genes responsible for type III and IV allergic reactions leading to the disease is associated with HLA-DR3. The increase of Bf S allotype and low mean factor B concentrations, however, can be explained by the strong linkage disequilibrium between BfS and HLA-DR3. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text