JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow
| Autor: | Florence Bardin, Vincent Frontera, Michel Aurrand-Lions, Stéphane J. C. Mancini, Marie-Laure Arcangeli, Susanne Adams, Christian Chabannon, Ralf H. Adams, Elodie Obrados, Claudine Schiff |
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| Přispěvatelé: | Centre de Recherche en Cancérologie de Marseille (CRCM / U891 Inserm), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Thérapie cellulaire et génique, Department of Tissue Morphogenesis [Münster], Max Planck Institute for Molecular Biomedicine, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Centre de Ressources Biologiques en Oncologie, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
MESH: Immunoglobulins MESH: Hematopoiesis Biochemistry MESH: Mice Knockout MESH: Hematopoietic Stem Cells Mice 0302 clinical medicine Bone Marrow MESH: Animals Mice Knockout 0303 health sciences medicine.diagnostic_test MESH: Bone Marrow Cells Hematology Hematopoietic Stem Cell Mobilization humanities Cell biology Haematopoiesis medicine.anatomical_structure MESH: Cell Adhesion Molecules [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Bone Marrow Stem cell Stromal cell Immunology education Immunoglobulins Bone Marrow Cells Biology Flow cytometry MESH: Cell Adhesion MESH: Hematopoietic Stem Cell Mobilization 03 medical and health sciences MESH: Mice Inbred C57BL MESH: Cell Proliferation Cell Adhesion medicine Animals MESH: Mice Cell Proliferation 030304 developmental biology Cell growth fungi Mesenchymal Stem Cells Cell Biology Hematopoietic Stem Cells MESH: Male Hematopoiesis Mice Inbred C57BL MESH: Mesenchymal Stromal Cells Bone marrow Cell Adhesion Molecules Function (biology) 030215 immunology |
| Zdroj: | Blood Blood, American Society of Hematology, 2011, 118 (17), pp.4609-19. ⟨10.1182/blood-2010-12-323972⟩ Blood, 2011, 118 (17), pp.4609-19. ⟨10.1182/blood-2010-12-323972⟩ |
| ISSN: | 0006-4971 1528-0020 |
| DOI: | 10.1182/blood-2010-12-323972⟩ |
| Popis: | In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1α BM content in jam-b−/− mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment. |
| Databáze: | OpenAIRE |
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