Diagnostic value of anti-neuronal antibodies for paraneoplastic disorders of the nervous system
| Autor: | J.W.B. Moll, M.E.L. van der Burg, Charles J. Vecht, S. C. Henzen-Logmans, Ted A.W. Splinter |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Nervous system
medicine.medical_specialty Pathology Lung Neoplasms Paraneoplastic Syndromes Fluorescent Antibody Technique Disease Nervous System Gastroenterology Anti neuronal antibodies Internal medicine Humans Medicine Carcinoma Small Cell Autoantibodies Neurons Ovarian Neoplasms Brain Diseases biology business.industry Autoantibody Brain Cancer medicine.disease Confidence interval Psychiatry and Mental health medicine.anatomical_structure biology.protein Female Surgery Neurology (clinical) Nervous System Diseases Antibody business Ovarian cancer Research Article |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 53:940-943 |
| ISSN: | 0022-3050 |
| Popis: | The diagnostic value of the presence of anti-neuronal antibodies in serum was examined in 21 patients suspected of paraneoplastic disorders of the nervous system (NS) (group 1) and was compared to three control groups; group 2: 25 patients with a neurological disease, without cancer and no sign of paraneoplastic disorder; group 3: 27 patients with neurological disease and cancer and no signs of a paraneoplastic disorder; group 4: 94 patients with cancer and without neurological disease. In group 1, anti-neuronal nuclear antibodies were detected in eight patients (38%), in titres from 1:1000 to 1:32,000. A small cell lung cancer was present in six patients, ovarian cancer in one patient and in one patient no tumour could be detected. The neurological symptoms preceded a diagnosis of cancer in five out of eight patients. Anti-neuronal antibodies were found in the serum of two out of 94 patients (2%) from control group 3 but not in serum from any of the other control groups. These data indicate a moderate sensitivity of 38%, but a high specificity of 98.6% (95% confidence interval 95.5-99.8%) for the presence of anti-neuronal nuclear antibodies if a paraneoplastic NS disorder is suspected. |
| Databáze: | OpenAIRE |
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