Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals
| Autor: | Nimedia Gideon Aitokhuehi, O. Bamidele, S A Onasanwo, James Adedayo Adebisi, Temitope Joshua Bankole, Gideon Opeyemi Ayilara, Boluwatife Adetoyin Adeboye, Lawrence Dayo Adedayo, Alaba Olumide Ojo, Funmileyi Olubanjo Awobajo |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemistry Cola nitida ved/biology Analgesic ved/biology.organism_classification_rank.species Neuroscience (miscellaneous) Propranolol (+)-Naloxone Pharmacology lcsh:RC321-571 03 medical and health sciences Atropine 030104 developmental biology 0302 clinical medicine Anesthesiology and Pain Medicine Nociception Opioid Muscarinic acetylcholine receptor medicine Neurology (clinical) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurobiology of Pain, Vol 5, Iss, Pp-(2019) |
| Popis: | Methanol extract of Cola nitida (MECN) was evaluated for its anti-inflammatory and analgesic activities using rats and mice. Inflammatory activity of MECN was assessed by carrageenan-induced paw oedema while analgesic activity was evaluated by acetic acid –induced writhing and formalin paw lick test. Histological analyses of the paws were also carried out. There was evaluation of the mechanism(s) of action of MECN using naloxone, a blocker of opioid receptors; atropine, blocker of muscarinic receptors; and propranolol, blocker of beta adrenergic receptors. Findings from the study revealed that MECN has both anti-inflammatory and analgesic properties. These properties were found to be dose dependent with 200 mg/kg of MECN discovered to be the most potent dose. 200 mg/kg was able to cause statistically significant reduction in paw size (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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