Resting-state functional connectivity of brain regions involved in cognitive control, motivation, and reward is enhanced in obese females
| Autor: | Jeroen van der Grond, Hanno Pijl, Marjolein A. Wijngaarden, Mirjam A. Lips, Serge A.R.B. Rombouts, Ilya M. Veer, Mark A. van Buchem, Gerrit H. de Groot |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Hypothalamus Medicine (miscellaneous) Striatum Gyrus Cinguli Amygdala Brain mapping Energy homeostasis Body Mass Index Cognition Reward Internal medicine medicine Humans Obesity Prefrontal cortex Brain Mapping Motivation Nutrition and Dietetics Resting state fMRI medicine.diagnostic_test business.industry Fasting Middle Aged Postprandial Period Magnetic Resonance Imaging Up-Regulation Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 Posterior cingulate Female Insulin Resistance Nerve Net Functional magnetic resonance imaging business |
| Zdroj: | American Journal of Clinical Nutrition, 100(2), 524-531 |
| Popis: | Background: The brain is crucial for the control of food intake, reward, and energy homeostasis. Objective: We hypothesized that 1) brain circuits involved in energy homeostasis and reward show different functional connectivity patterns between obese and lean individuals and 2) food intake affects functional connectivity differentially in obese and lean. Therefore, we compared the connectivity of the hypothalamus, amygdala, and posterior cingulate cortex, each probing a distinct network related to energy homeostasis and reward, between obese subjects and lean subjects in the fasting state and after meal ingestion. Design: We acquired 3 Tesla resting-state functional magnetic resonance imaging scans after an overnight fast and after ingestion of a liquid mixed meal in 46 obese female participants [19 with normal glucose tolerance and 27 with type 2 diabetes mellitus (T2DM)] and 12 lean subjects. Functional connectivity of our regions of interest was assessed by using a seed-based correlation approach. Results: No significant differences between normal-glucose-tolerant and T2DM subjects were observed. In the fasting state, the total obese group had stronger hypothalamic connectivity with the medial prefrontal cortex and the dorsal striatum than did the lean subjects. The amygdala was differentially connected to the right insula in obese compared with lean subjects. Food intake dampened hypothalamic connectivity with the frontal regions in lean subjects, whereas these connections were barely affected in obese subjects. Conclusions: Our results indicate that functional connectivity in several brain networks, particularly the homeostatic and cognitive control network and the reward network, was different between obese and lean subjects. In the fasting state, obesity appears to be associated with stronger functional connectivity between brain areas involved in cognitive control, motivation, and reward, whereas these connections are largely unaffected by food intake in obese compared with lean subjects. This trial was registered at clinicaltrials.gov as NCT01167959. Am J Clin Nutr doi: 10.3945/ajcn.113.080671. |
| Databáze: | OpenAIRE |
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