Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma
| Autor: | Dimitrios Xynopoulos, J Yotis, Niki Arnogianaki, George A. Plataniotis, Niki Agnanti, Maroulio Talieri, Andreas Scorilas, Sofia Papadopoulou |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adenoma
Adult Male Cancer Research Colon Cathepsin D Colorectal adenoma Cathepsin B Antigen Cathepsin B/*biosynthesis Biomarkers Tumor medicine Cathepsin D/*biosynthesis Humans Neoplasm Invasiveness Lymph node Aged Carcinoma/metabolism/*pathology Aged 80 and over CD antigen Chemistry Carcinoma Middle Aged Colorectal Neoplasms/metabolism/*pathology medicine.disease Immunohistochemistry Colon/metabolism medicine.anatomical_structure Oncology Tumor Markers Biological Adenoma/metabolism/*pathology Disease Progression Cancer research Adenocarcinoma Neoplasm Invasiveness/pathology Female Colorectal Neoplasms |
| Zdroj: | Cancer Letters. 205:97-106 |
| ISSN: | 0304-3835 |
| Popis: | Lysosomal proteinases, cathepsin B (CB) and cathepsin D (CD) have been implicated in the progression of several human tumors. In the present study, the antigen levels of CB and CD, and their immunohistochemical staining were compared in paired colorectal tumors (n =64) and background colon tissue of the same patients with clinicopathological staging. The antigen levels, were found to be significantly higher in cancer tissue (mean 35.79 ng/mg protein for CB and 3.97 ng/mg protein for CD) than in corresponding normal mucosa (24.62 ng/mg protein for CB and 2.69 ng/mg protein for CD). CB antigen levels were positively correlated with differentiation grade and Duke's stage (P < 0.001 and P = 0.041, respectively), but not correlated with nodal status. CD antigen levels were not correlated with the previous parameters. Staining intensity for both antigens increased from adenoma to adenocarcinoma. The degree of staining for CB and CD was associated with differentiation grade (P = 0.004 and 0.001, respectively), Dukes' stage (P = 0.002 and 0.001, respectively) and lymph node involvement (P = 0.002 and P < 0.001, respectively). Cancer Lett |
| Databáze: | OpenAIRE |
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