Osteopontin expression in progressive renal injury in remnant kidney: Role of angiotensin II
| Autor: | Xue Q. Yu, Richard J. Johnson, Leonard L. Wu, Richard E. Gilbert, Kar N. Lai, Xiao R. Huang, Hui Y. Lan, Mark E. Cooper, Niansheng Yang |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Pathology Sialoglycoproteins Gene Expression Tetrazoles Angiotensin-Converting Enzyme Inhibitors Blood Pressure Kidney urologic and male genital diseases valsartan Rats Sprague-Dawley Ramipril stomatognathic system Internal medicine medicine nephrectomy Animals RNA Messenger Kidney surgery Osteopontin Antihypertensive Agents In Situ Hybridization Angiotensin II receptor type 1 biology business.industry Angiotensin II rampiril Valine Blotting Northern medicine.disease adhesion molecule Rats macrophages Disease Models Animal Endocrinology medicine.anatomical_structure Nephrology Renal physiology Tubulointerstitial fibrosis biology.protein Nephritis Interstitial business Kidney disease tubulointerstitial injury |
| Zdroj: | Kidney International. (4):1469-1480 |
| ISSN: | 0085-2538 |
| DOI: | 10.1046/j.1523-1755.2000.00309.x |
| Popis: | Osteopontin expression in progressive renal injury in remnant kidney: Role of angiotensin II.BackgroundOsteopontin (OPN) is a macrophage chemotactic and adhesion molecule and has been shown to play a role in glomerular and tubulointerstitial injury in several kidney disease models.MethodsThe present study examined whether OPN expression is involved in the progression of renal disease following subtotal (5/6) nephrectomy (STNx) in rats and whether angiotensin II (Ang II) mediates the up-regulation of renal OPN expression and macrophage accumulation in this model by administering valsartan, an Ang II type I (AT1) receptor antagonist, or ramipril, an angiotensin-converting enzyme (ACE) inhibitor.ResultsIn normal and sham-operated rat kidneys, OPN was expressed in a few tubules ( |
| Databáze: | OpenAIRE |
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