Cell cycles in human diploid and aneuploid strains
| Autor: | V. I. Kukharenko, A. M. Kuliev, V. V. Terskikh, K. N. Grinberg |
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| Rok vydání: | 1974 |
| Předmět: |
Male
Time Factors Cell Chromosome Disorders Trisomy Biology Tritium Trisomy 9 Cell Line Andrology Klinefelter Syndrome Chromosomes Human 21-22 and Y Genetics medicine Humans Fibroblast Cells Cultured Genetics (clinical) Skin Chromosome Aberrations Chromosomes Human 6-12 and X Chromosome 7 (human) Karyotype Fibroblasts Cell cycle Aneuploidy medicine.disease Diploidy medicine.anatomical_structure Autoradiography Female Down Syndrome Ploidy Chromosome 21 Cell Division Thymidine |
| Zdroj: | Human Genetics. 24:285-296 |
| ISSN: | 1432-1203 0340-6717 |
| Popis: | Autoradiographic investigation of the cell cycle of 12 diploid and 12 abnormal human fibroblast strains was carried out. Two cell strains (trisomy 7 and monosomy 21) derived from spontaneous abortuses showed prolongation of the G2 period accompanied by the shortening of the S period. Other cytogenetically abnormal embryonic strains (trisomy 9, 14 and triploidy) did not deviate from the diploid pattern. Three cell strains (LHC-1-70, LHC-6-70, LHC-411) derived from the patients with karyotypes 47,XXX, 47,XY,+18 and 46,XX,5p—respectivly had embryonic types of proliferation with a short G2 period. In two other strains from the patients with Down's syndrom the G2 period was prolonged. There was no statistically significant difference in the parameters of the cell cycle between the control and the strains derived from a patient with Klinefelter syndrom and from a male patient with karyotype 46,XX. The modificatory effect of the chromosomal abnormalities on the parameters of cell cycle is discussed. |
| Databáze: | OpenAIRE |
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