Estrogen receptor alpha XbaI GG genotype was associated with severe preeclampsia
| Autor: | Minoo Yaghmaei, Saeedeh Salimi, Farzaneh Farajian-Mashhadi, Mahnaz Shahrakipour, Ehsan Tabatabaei, Mojgan Mokhtari |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Genotype Physiology Estrogen receptor Blood Pressure Biology Iran Severity of Illness Index Preeclampsia 03 medical and health sciences Young Adult 0302 clinical medicine Pre-Eclampsia Polymorphism (computer science) Pregnancy Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease Allele Gene Alleles Gynecology Polymorphism Genetic Estrogen Receptor alpha General Medicine medicine.disease 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Case-Control Studies Gestation Female Estrogen receptor alpha |
| Zdroj: | Clinical and experimental hypertension (New York, N.Y. : 1993). 39(3) |
| ISSN: | 1525-6006 |
| Popis: | Estrogen receptor-α (ERα) plays an essential role in the adaptation of increased uterine blood flow during gestation. Therefore, ERα gene could be a possible candidate for preeclampsia (PE) susceptibility. In current study we aimed to investigate the association of the ERα gene polymorphisms and PE in an Iranian population.A total of 192 pregnant women with PE and 186 normotensive women were genotyped for ERα gene (PvuII and XbaI) polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method.The frequencies of alleles and genotypes of ERα PvuII and XbaI polymorphisms were not different between PE and normotensive control women. However, higher frequency of GG genotype was observed in women with severe PE compared to mild PE (OR, 1.8 [95% CI, 1.1 to 3]; p = 0.02) and in severe PE compared to normotensive women [OR = 1.8 (1.1-3), p = 0.02] after adjusting for age, ethnicity, and primiparity.The GG genotype of ERα XbaI polymorphism could be a genetic risk factor for PE predisposition. |
| Databáze: | OpenAIRE |
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