Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
| Autor: | Marla Dubinsky, David M. Underhill, Courtney A. Becker, Vincent Funari, Kent D. Taylor, Phillip Fleshner, Hanlin L. Wang, Jerome I. Rotter, Quoclinh Nguyen, Christopher N. Reyes, Jordan Brown, Iliyan D. Iliev, Gordon D. Brown, Dermot P.B. McGovern, Samuel P. Strom |
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| Rok vydání: | 2012 |
| Předmět: |
Colon
Colony Count Microbial Biology Polymorphism Single Nucleotide Inflammatory bowel disease Microbiology Mice Immune system Intestinal mucosa C-type lectin Immunity medicine Animals Humans Lectins C-Type Candida tropicalis Intestinal Mucosa Colitis Immunity Mucosal Antibodies Fungal Multidisciplinary Innate immune system CLEC7A Dextran Sulfate Fungi medicine.disease Immunity Innate Intestines Mice Inbred C57BL Haplotypes Immunology Metagenome Colitis Ulcerative Female Disease Susceptibility |
| Zdroj: | Science. 336:1314-1317 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1221789 |
| Popis: | The Mycobiome In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what about fungi? Iliev et al. (p. 1314 ) now report that mice and humans, along with several other mammals, contain a resident intestinal population of fungi. Deletion of Dectin-1, which acts as a major innate immune sensor for fungi, led to enhanced susceptibility and worse pathology in a chemically induced model of colitis in mice. A polymorphism in the gene that encodes Dectin-1 has been observed in patients with ulcerative colitis, which hints that, besides the traditional bacterial microbiome, alterations in the “mycobiome” may also play a role in health and disease. |
| Databáze: | OpenAIRE |
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