Interaction Between Diabetes Mellitus and Platelet Reactivity in Determining Long-Term Outcomes Following Percutaneous Coronary Intervention

Autor: Marialessia Capuano, Elisabetta Ricottini, Michele Matia Viscusi, Germano Di Sciascio, Fabio Mangiacapra, Ilaria Cavallari, Emanuele Barbato, Edoardo Bressi, Iginio Colaiori, Silvia Spoto
Přispěvatelé: Mangiacapra, F., Bressi, E., Colaiori, I., Ricottini, E., Cavallari, I., Capuano, M., Viscusi, M. M., Spoto, S., Barbato, E., Di Sciascio, G.
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Time Factors
Platelet Aggregation
Physiology
medicine.medical_treatment
Drug Resistance
Myocardial Infarction
Pharmaceutical Science
030204 cardiovascular system & hematology
Coronary artery disease
Percutaneous coronary intervention
0302 clinical medicine
Risk Factors
Long term outcomes
Clinical endpoint
Prospective Studies
Myocardial infarction
Genetics (clinical)
Aspirin
Dual Anti-Platelet Therapy
Middle Aged
Clopidogrel
Treatment Outcome
Cardiology
Molecular Medicine
Female
Stents
Platelet function
Cardiology and Cardiovascular Medicine
medicine.drug
Diabetes mellitu
medicine.medical_specialty
Risk Assessment
Platelet reactivity
03 medical and health sciences
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Genetics
medicine
Humans
cardiovascular diseases
Aged
Pharmacology
business.industry
Coronary Thrombosis
medicine.disease
030104 developmental biology
Conventional PCI
business
Platelet Aggregation Inhibitors
Mace
Zdroj: Journal of Cardiovascular Translational Research. 13:668-675
ISSN: 1937-5395
1937-5387
Popis: Diabetes mellitus (DM) is an independent predictor of adverse outcomes in patients with coronary artery disease (CAD). We investigated the interaction between DM and high platelet reactivity (HPR) in determining long-term clinical outcomes after percutaneous coronary intervention (PCI). We enrolled 500 patients who were divided based on the presence of DM and HPR. Primary endpoint was the occurrence of major adverse clinical events (MACE) at 5 years. Patients with both DM and HPR showed the highest estimates of MACE (37.9%, log-rank p
Databáze: OpenAIRE
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