Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats
| Autor: | Felipe C. Damatto, Leonardo A. M. Zornoff, David Rafael Abreu Reyes, Ana Angélica Henrique Fernandes, Ingrid F. Tosta, Katashi Okoshi, Aline R. R. Lima, Lidiane M. Souza, E A Rodrigues, Luana Urbano Pagan, Paula F. Martinez, Mariana Janini Gomes, Marina Politi Okoshi, T H D Pontes |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Federal University of Mato Grosso do Sul |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Lipid Peroxides Satellite Cells Skeletal Muscle Physical exercise medicine.disease_cause Antioxidants Superoxide dismutase 03 medical and health sciences Electrocardiography 0302 clinical medicine physical exercise Internal medicine Physical Conditioning Animal gastrocnemius medicine Aerobic exercise Animals Rats Wistar Muscle Skeletal Aerobic capacity chemistry.chemical_classification Reactive oxygen species biology Ventricular Remodeling business.industry Glutathione peroxidase Heart Resistance Training Cell Biology Original Articles echocardiogram Oxidative Stress 030104 developmental biology Endocrinology myocardial infarction chemistry 030220 oncology & carcinogenesis biology.protein Molecular Medicine Original Article business Cell activation Reactive Oxygen Species Oxidation-Reduction Oxidative stress |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Cellular and Molecular Medicine |
| Popis: | Made available in DSpace on 2020-12-12T02:38:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI-induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S-MI); aerobic exercised MI (A-MI); and resistance exercised MI (R-MI). Exercised rats trained three times a week for 12 weeks on a treadmill or ladder. Statistical analysis was performed by ANOVA or Kruskal-Wallis test. Functional aerobic capacity was greater in A-MI and strength gain higher in R-MI. Echocardiographic parameters did not differ between infarct groups. Reactive oxygen species production, evaluated by fluorescence, was higher in S-MI than Sham, and lipid hydroperoxide concentration was lower in A-MI than the other groups. Glutathione peroxidase activity was higher in A-MI than S-MI and R-MI. Superoxide dismutase was lower in S-MI than Sham and R-MI. Gastrocnemius cross-sectional area, satellite cell activation and expression of the ubiquitin-proteasome system proteins did not differ between groups. In conclusion, aerobic exercise and resistance exercise improve functional capacity and maximum load carrying, respectively, without changing cardiac remodelling in infarcted rats. In the gastrocnemius, infarction increases oxidative stress and changes antioxidant enzyme activities. Aerobic exercise reduces oxidative stress and attenuates superoxide dismutase and glutathione peroxidase changes. Botucatu Medical School Sao Paulo State University UNESP School of Physical Therapy Federal University of Mato Grosso do Sul Institute of Biosciences Sao Paulo State University UNESP Botucatu Medical School Sao Paulo State University UNESP Institute of Biosciences Sao Paulo State University UNESP FAPESP: 2014/21972-3 FAPESP: 2014/23592-3 CNPq: 308557/2018-2 CNPq: 310876/2018-4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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