Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
| Autor: | Shanping Li, Didier Doumtabe, Safiatou Doumbo, Carrie L. Anderson, Peter D. Crompton, Silvia Portugal, Tuan M. Tran, Erik L. Allman, Jeff Skinner, Christine S. Hopp, Craig Martens, Marie-Esther N’Dri, Catherine Lavazec, Manuel Llinás, Stacy M. Ricklefs, Volker Winkler, Nuno S. Osório, Kassoum Kayentao, Thomas Lavstsen, Mario Recker, Louise Turner, Hamidou Cisse, Muhammad Asghar, Hannah Fleckenstein, Dan E. Sturdevant, Richard Thomson-Luque, Julia Hibbert, Manijeh Vafa Homann, Thomas D. Otto, Kimmo Virtaneva, Aissata Ongoiba, Joana Martins, Boubacar Traore, Nathalia F. Lima, Anna Färnert, Moussa Niangaly, Carolina M. Andrade |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Erythrocytes Adolescent Endemic Diseases Genotype Plasmodium falciparum Mali Asymptomatic General Biochemistry Genetics and Molecular Biology Host-Parasite Interactions Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Dry season parasitic diseases medicine Animals Humans Parasite hosting Malaria Falciparum Child Asymptomatic Infections Subclinical infection biology Transmission (medicine) Infant General Medicine Middle Aged medicine.disease biology.organism_classification 3. Good health 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis Immunology Female Seasons medicine.symptom Malaria |
| Zdroj: | Nature Medicine |
| ISSN: | 1078-8956 |
| Popis: | The dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquito vectors to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the human host or compromising host survival, is poorly understood. Here we show that low levels of P. falciparum parasites persist in the blood of asymptomatic Malian individuals during the 5- to 6-month dry season, rarely causing symptoms and minimally affecting the host immune response. Parasites isolated during the dry season are transcriptionally distinct from those of individuals with febrile malaria in the transmission season, coinciding with longer circulation within each replicative cycle of parasitized erythrocytes without adhering to the vascular endothelium. Low parasite levels during the dry season are not due to impaired replication but rather to increased splenic clearance of longer-circulating infected erythrocytes, which likely maintain parasitemias below clinical and immunological radar. We propose that P. falciparum virulence in areas of seasonal malaria transmission is regulated so that the parasite decreases its endothelial binding capacity, allowing increased splenic clearance and enabling several months of subclinical parasite persistence. |
| Databáze: | OpenAIRE |
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