Cardiovascular effects of microinjections of adenosine analogs into the fourth ventricle of rats
| Autor: | Eugene P. Schoener, W. Richard Campbell, M. Parizon, Robin A. Barraco, Stacey E. Shehin |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Adenosine Time Factors Vasodilator Agents Central nervous system Blood Pressure Adenosine-5'-(N-ethylcarboxamide) Pharmacology Cardiovascular control Fourth ventricle Cerebral Ventricles Cardiovascular Physiological Phenomena chemistry.chemical_compound Heart Rate Heart rate medicine Animals Molecular Biology Injections Intraventricular Dose-Response Relationship Drug business.industry General Neuroscience Rats Inbred Strains Rats medicine.anatomical_structure Blood pressure chemistry Anesthesia Microinjections Phenylisopropyladenosine Neurology (clinical) Caffeine business Developmental Biology medicine.drug |
| Zdroj: | Brain research. 424(1) |
| ISSN: | 0006-8993 |
| Popis: | Rats were implanted with chronic indwelling cannulae into the posterior region of the fourth ventricle. After recovery from surgery, acute experiments on blood pressure were conducted under urethane anesthesia. The blood pressure and heart rate responses following administration of two adenosine analogs, NECA and L-PIA were examined. Microinjections of both analogs produced dose-dependent reductions in blood pressure and heart rate. NECA was appoximately 20-fold more potent than L-PIA in reducing blood pressure and depressing heart rate. The cardiovascular effects of both analogs were antagonized by parenteral injections of caffeine. These findings show that microinjections of analogs of adenosine into the fourth ventricle can influence areas of the central nervous system involved in cardiovascular control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|