Effect of oral l-arginine supplementation on post-exercise blood pressure in hypertensive adults: A systematic review with meta-analysis of randomized double-blind, placebo-controlled studies

Autor: Alves Porto, A. [UNESP], Almeida Gonzaga, L. [UNESP], Benjamim, C. J.R. [UNESP], Garner, D. M., Adami, F., Valenti, V. E. [UNESP]
Přispěvatelé: Universidade Estadual Paulista (UNESP), Universidade de São Paulo (USP), Headington Campus, ABC Medical School (FMABC)
Rok vydání: 2022
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0765-1597
DOI: 10.1016/j.scispo.2021.04.003
Popis: Made available in DSpace on 2022-04-29T08:38:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Objectives: We studied the effects of oral L-arginine on post-exercise blood pressure (BP). Update: Throughout October 2020 and February 2021, the electronic databases Medline, Web of Science, CINAHL, Embase, Cochrane, Bireme, Open Gray, MedRxiv, Clinical Trials and Scopus were considered. The terms enforced to search randomized, double-blind and placebo-controlled clinical trials were, “Arginine” AND “Post-exercise”. Three studies were involved in the meta-analysis, the original results of the three studies demonstrated a trend related to L-arginine intervention. The 95% CI ranged from −7.94 to −2.14 with a combined effect size of −5.04 for systolic BP and −4.96 to −0.97 with a combined effect size of −2.96 for diastolic BP. Perspectives and projects: Our meta-analysis revealed a combined effect size of 3.40 (P = 0.0007) for systolic BP and 2.91 (P = 0.004) for diastolic BP supportive of L-arginine intervention. Conclusions: Our review delivers evidence that oral L-arginine supplementation has the potential to reduce post-exercise systolic and diastolic BP in hypertensive patients. Department of Physical Therapy Faculty of Sciences and Technologies UNESP Presidente Prudente Department of Internal Medicine Ribeirao Preto Medical School University of Sao Paulo (FMRP/USP) Cardiorespiratory Research Group Department of Biological and Medical Sciences Faculty of Health and Life Sciences Oxford Brookes University Headington Campus Epidemiology and Data Analysis Laboratory ABC Medical School (FMABC) Center for the Study of the Autonomic Nervous System (CESNA) UNESP Department of Physical Therapy Faculty of Sciences and Technologies UNESP Presidente Prudente Center for the Study of the Autonomic Nervous System (CESNA) UNESP
Databáze: OpenAIRE
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